I use 64-bit Ubuntu on my workstation at work. It needs to be 64-bit because I use 64-bit images of Red Hat for development and testing. Most software that I need works well with the exception of flash in Firefox.
I never really cared too much about this at work before since I usually don't visit a lot of flash based sites. Although it did kind of suck not being able to play the cool YouTube video all of my coworkers were watching.
Well, after my last blog entry caused my work browser to crash I decided to do something about it. I found some great directions in the Ubuntu Forums that cover many options. The one that worked for me was the Nspluginwrapper script (towards the end).
Until Adobe gets of their butt and makes a 64-bit version of their latest flash, this is a good alternative.
You can't drink all day if you don't start in the morning.